p43 induces IP-10 expression through the JAK-STAT signaling pathway in HMEC-1 cells

The Jak-Stat Signaling Pathway of Interferons System: Snapshots

Interferons (IFNs) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. Although IFNs have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. IFNs exert their pleiotropic effects through their multisubunit cell surface recept...

the jak-stat signaling pathway of interferons system: snapshots

interferons (ifns) are a family of small regulatory glycoproteins that play a central role in the defense against viral infections. although ifns have been initially discovered as antiviral factors, today they are known as an integral part of the cytokine network that affect a wide range of biological processes. ifns exert their pleiotropic effects through their multisubunit cell surface recept...

The JAK/STAT signaling pathway.

The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. JAK activation stimulates cell prolifer...

Prolactin regulates ZnT 2 expression through the JAK 2 / STAT 5 1 signaling pathway in mammary cells

28 The zinc transporter ZnT2 (SLC30A2) plays an important role in zinc secretion into milk during 29 lactation. The physiological process of mammary gland secretion is regulated through complex 30 integration of multiple lactogenic hormones. Prolactin plays a primary role in this regulation 31 through the activation of various signaling cascades including Jak2/STAT5, MAPK, p38 and 32 PI3K. The ...

The JAK-STAT Signaling Pathway: Input